Combined consumption of a single high-dose vitamin A supplement and provision of vitamin A fortified oil to households maintains adequate milk retinol concentrations for 6 months in lactating Moroccan women

Abstract Number Theme Presentation Type Cover Approved
0094 Effects of interventions on micronutrient content of breastmilk Oral Not Approved


Abstract Content


To evaluate the effect of post-partum high dose VA supplementation and provision of VA fortified oil for household consumption on plasma and milk retinol concentrations of lactating Moroccan women during the first 6 mo post-partum.


Lactating women aged 19-40 y received a VA supplement within the first mo post-partum and thereafter were randomly assigned to one of two groups to receive weekly vitamin A fortified oil (FO) or non-fortified oil (NFO) for home consumption for 6 months. Blood was collected at baseline, 3 and 6 mo for measurement of plasma retinol concentration; milk was collected monthly for measurement of milk retinol and fat concentrations.


Serum retinol concentration was higher in the FO group than in the NFO group at 6 mo post-partum (3.5±0.6 µmol/L vs. 2.8±0.6 µmol/L, P<0.0001). Milk retinol concentration was greater from 1 mo post-partum in the FO group compared to the NFO group and remained higher throughout 6 mo (P<0.0001). Milk retinol per g fat at baseline did not differ by group; by 3 mo post-partum, milk retinol per g fat was higher in the FO group than in the non-FO group (87.3 ± 43 vs 77.3 ± 59 nmol/g fat, p=0.02) and remained higher throughout 6 mo (P<0.0001).


Combined supplementation and fortification has a more sustained impact on milk retinol concentrations than supplementation alone.

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