Daily lipid-based nutrient supplements containing 800 µg Vitamin A increased serum retinol-binding protein in lactating but not in pregnant women in rural Bangladesh

Abstract Number Theme Presentation Type Cover Approved
0295 Efficacy or effectiveness of micronutrient interventions Poster Not Approved


Abstract Content


Vitamin A deficiency during pregnancy and lactation is still common in Bangladesh. We evaluated the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on vitamin A status.


We conducted a cluster-randomized effectiveness trial (the Rang-Din Nutrition Study) in which women received iron and folic acid (IFA; 60 mg iron + 400 µg folic acid) or LNS-PL (20 g/d, 118 kcal) containing essential fatty acids and 22 vitamins and minerals (including 800 µg of vitamin A). LNS-PL was consumed daily during pregnancy and 6 mo postpartum; IFA was consumed daily during pregnancy and on every alternate day during the first 3 mo postpartum. Low vitamin A status was defined as RBP <1.17 µmol/L.


We analyzed serum samples of 1125, 875, and 1040 women at baseline (~13 wk gestation), 36 wk gestation and 6 mo postpartum, respectively. Mean log RBP did not differ significantly between groups at baseline and at 36 wk gestation, but was higher in the LNS-PL group at 6 mo postpartum (p = 0.0074). The prevalence of low vitamin A status was 30.8% and 28.0% at baseline, 27.5% and 23.4% at 36 wk and 24.1% and 20.7% at 6 mo postpartum in the IFA and LNS-PL groups, respectively.


About one-fourth of women in this area of rural Bangladesh had low vitamin A status in pregnancy and the first 6 mo postpartum. LNS-PL supplementation increased mean RBP at 6 mo postpartum but not at 36 wk gestation.

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