Iron-folic acid supplementation during pregnancy reduces the risk of stunting in children less than 2 years of age; a retrospective cohort study from Nepal

Abstract Number Theme Presentation Type Cover Approved
0053 Functional outcomes: e.g. child development, cognition, growth, stunting, birth outcomes, morbidity, long-term health Poster Not Approved


Abstract Content


The aim of the study was to investigate the effect of antenatal iron-folic acid (IFA) supplementation on child stunting in Nepalese children age <2 years.


A retrospective cohort study design was used, in which a pooled cohort of 5,235 most recent live births 2 years prior to interview from three Nepal Demographic and Health Surveys (2001, 2006 and 2011) was analysed. The primary outcome was stunting in children age <2 years. The main exposure variable was antenatal IFA supplementation. Multivariate Poisson regression analysis was performed, adjusted for sampling design and 26 potential confounding factors.


In our sample, 31% and 10% of Nepalese children age <2 years were stunted and severely stunted, respectively. The adjusted relative risk of being stunted was 14% lower in children whose mothers used IFA supplements compared to those whose mothers did not use (aRR = 0.86, 95% CI = 0.77-0.97). Additionally, the adjusted relative risk of being stunted was significantly reduced by 23% when antenatal IFA supplementation was started =6 months with =90 IFA supplements used during pregnancy (aRR = 0.77, 95% CI = 0.64-0.92). Universal coverage of prenatal IFA supplementation initiated =6 months with =90 supplements used during pregnancy could prevent stunting in an estimated 16,800 Nepalese children <2 years annually.


Antenatal IFA supplementation significantly reduced the risk of stunting in Nepalese children age <2 years. The greatest impact on the risk reduction of child stunting was when IFA supplements were started =6 months with =90 supplements were used.

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