Is there an increased risk of iodine deficiency among reproductive-age women (18-45) with “normal” thyroid function?

Abstract Number Theme Presentation Type Cover Approved
0479 Efficacy or effectiveness of micronutrient interventions Poster Not Approved


Abstract Content


To investigate efficacy of iodine supplementation in 18-45-yr iodine deficient women in improving iodine status, thyroid function, and body composition.


6-month randomized controlled trial. Non-pregnant (euthyroid, normal thyroid stimulating hormone (TSH), mean=1.57 µU/mL) women were randomized into two groups: 12.5mg iodine (IG, n=65) or placebo (PG, n=38). Assessments: iodine status (24-hr urine iodine (UI), %-iodine saturation (%IS), sodium-iodide-symporter-ratio (NIS)), body composition analysis using Dual Energy X-ray Absorptiometry, resting metabolic rate (RMR), thyroid function (TSH, free thyroxine (T4), free tri-iodithyronine (T3), thyroglobulin and thyroid peroxidase antibodies, 3-day diet records, health history and physical activity questionnaires.


>90% reported reduced salt intake in diets, no knowledge of dietary sources of iodine, and did not know difference between iodized vs. regular table salt. Median consumption of dietary iodine was <100 µg/day, significantly <150 µg/day RDA for iodine, <250 µg/day (pregnancy and lactation). Mean baseline data (N=108) showed UI of 35.52mg/24hr vs >44 mg/24hr, %IS 70.93% vs >90%, and NIS-ratio 27.86 vs 28-74, between study population and expected mean, respectively, indicating iodine deficiency. Of those completing study (n=64; IG, n=32, PG, n=32), UI increased from 34.9-38.1 mg/24hr, %IS from 69.8-76.3%, and RMR from 1586-1628 Kcals. Between groups UI increased from 35.8-39.6 mg/24hr (IG) vs 34.0-36.6 mg/24hr (PG), %IS from 71.6-79.3% (IG) vs 67.9-73.2 (PG), and RMR from 1600-1650 Kcals (IG) vs 1572-1607 Kcals (PG).


Iodine supplementation may improve overall iodine nutrition status in reproductive-age women with decreased dietary iodine intakes that are especially vulnerable to the detrimental maternal and fetal effects of iodine deficiency.

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