Indicators of bone remodeling were evaluated during pregnancy in women of low economic status attending in public hospitals (Nazareth and Manga) from Barranquilla (Colombia).
This study is descriptive exploratory with longitudinal design. 84 pregnant adult were invited to donate blood samples and urine fasting 12 hours on the first (8-12 weeks) (1T), second (20-25 weeks) (2T) and third (32-36 weeks) (3T) trimester. In serum were determined by colorimetric method total calcium (SCa), total phosphatase activity (SPT), phosphatase of bone origin activity (SPB), and by ELISA levels of type I collagen telopeptide (SNTx) and osteocalcin (SOs). In Urine were determined by colorimetric method total calcium levels (UCa), creatinine (UCreat) and hydroxyproline (UHp).
Levels of Sca were 9.61±2; 7.64±2.9 and 8.64±2.41 mg/dL at 1T, 2T y 3T, respectively, being higher (p<0.01) in women attending at the hospital Nazareth. UCa levels also decreased during pregnancy, 8.55±5.60 and 5.65±4.53 mg/dL at 2T and 3T. UHp/Ucreat ratio tended to increase at 3T. SNTx were high in whole gestation averaging 122±48 ng/mL. SPT and SPB increased with advancing of gestation, and SOs had a tendency to decrease at the end of the period but no significant difference in the variation, with values 5.2±4.7; 4.7±2.7; and 3.0±1.8 ng/mL, in 1T, 2T and 3T, respectively.
These results suggest that in women of low socioeconomic status, calcium to meet the needs of pregnancy may result from adjustment mechanisms such as increased renal resorption and osteoclastic and osteoblastic activity of bone remodeling.