Normalization of vitamin D status with 1200 IU of vitamin D daily supports a leaner body mass phenotype in young infants

Abstract Number Theme Presentation Type Cover Approved
0306 Iron, zinc, vitamin A, iodine, vitamin B12, folate, vitamin D, multiple micronutrients Oral Not Approved


Abstract Content


Infants with plasma 25-hydroxyvitamin D [25(OH)D] over 75 nmol/L have a leaner body phenotype. The objective was to assess fat and lean mass accretion in infants with low vitamin D (LOW-D) status.


Term-born, breastfed infants from a dose-response study (Montreal, Canada) were categorized as LOW-D status (n=19) < 50 nmol/L at 1 mo of age and receiving 400, 800 or 1200 IU/d of vitamin D; and compared to a reference group with 25(OH)D > 50 nmol/L and receiving 400 IU/d of vitamin D. At 1 and 3 mo, measurements were anthropometry, body composition (dual-energy x-ray absorptiometry), plasma 25(OH)D (LC-MS/MS) and insulin like growth factor-1 (IGF-1; ELISA). Demographic and pregnancy information were surveyed.


At 1 mo, anthropometry and maternal characteristics were not different among groups. Plasma 25(OH)D at 1 mo was 37.0 (9.3) nmol/L in the LOW-D vs. 73.9 (19.1) nmol/L in the reference group. LOW-D infants that received 400 (n=7) to 800 IU/d (n=5) of vitamin D/d did not reach 75 nmol/L by 3 mo whereas 1200 IU/d (n=7) elevated 25(OH)D to above 75 nmol/L. Accretion of fat mass was greater, and lean mass lower, in LOW-D infants compared to the reference group; unless provided 1200 IU/d of vitamin D. IGF-1 declined more rapidly (LOW-D -31.2 vs reference -23.1 % change) in the LOW-D group.


Enhancing vitamin D status early in infancy may support a leaner body phenotype. Trials using higher dose vitamin D supplementation for neonates with low vitamin D status are required to confirm this hypothesis.

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