Vitamin D fortified milk: dose response study

Abstract Number Theme Presentation Type Cover Approved
0348 Efficacy or effectiveness of micronutrient interventions Poster Not Approved


Abstract Content


To evaluate the effects of different doses of vitamin D in milk on serum 25(OH)Vitamin D and PTH levels of selected 20- 50 year old men and women.


Interested participants underwent: 1) initial interview using screening checklist, 2) anthropometric measurements, 3) blood test for related bio-chemical markers, and 4) determination of serum 25(OH)Vitamin D, calcium and PTH levels. There were 159 qualified participants who were randomly allocated into three groups: Vitamin D dose of 600 IU per day (High dose group), 200 IU per day (Low dose group) and unfortified milk. Milk was administered once daily for 6 months.


Significant increases were seen in the 25(OH)Vitamin D levels of the participants: the highest mean difference in the high dose group from baseline to endline was 10.3152 nmol/L; for the low dose group the mean difference was 5.9864 nmol/L and the lowest mean difference was from the unfortified group (5.2167 nmol/L). The greatest decrease in PTH levels was from the high dose group (p-value= 0.011) followed by the low dose (p-value=0.021) and was lowest in the unfortified group.


High dose of Vitamin D fortification in milk resulted in higher increments in plasma 25(OH)Vitamin D levels than either low dose Vitamin D and unfortified milk among adults aged 20 to 50 years old.

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