A double-blind randomized placebo-controlled trial evaluating the effect of micronutrient powder (MNP) on urinary iodine levels of Filipino children aged 4 – 6 years

Abstract Number Theme Presentation Type Cover Approved
0339 Iron, zinc, vitamin A, iodine, vitamin B12, folate, vitamin D, multiple micronutrients Poster Not Approved


Abstract Content


To determine the effect of MNP (90 ug iodine) given for 16 weeks on iodine status of children aged 4-6 years old


In this randomized, double-blind, placebo-controlled trial, coded sachets with 1.0 g MNP (15 micronutrients; 90 ug iodine) or 1.0 g placebo were added to rations of children enrolled in a supplementary feeding program. Sample size (N=230) was based on the primary outcome of urinary iodine concentration (UIC) (a=0.05; power= 80%). UIC was measured using ammonium persulfate digestion with detection of the Sandell-Kolthoff reaction. Median UIC were compared using the Mann-Whitney U test on an intention-to-treat basis.


Informed consent was obtained for children randomly allocated to MNP (N=182) and control (CON; n=178). Socio-demographic characteristics, compliance, and utilization of iodized salt was similar. The proportion of stunted children was lower for MNP(19.7 vs 26.9; p<0.01). Baseline median UIC (ug/L) was similar at 172 (CON) and 174 (MNP). The proportion of children with UIC within the “moderate-severe” range was 19% (CON) and 21% (MNP). The median UIC of MNP was significantly higher (234 ug/L; p<0.0001) compared to CON (158 ug /L) at endline. The proportion of children with median UIC in the “moderate-severe” range in MNP (6.6%) was half of CON (12.3%).


MNP with 90 ug iodine at 60 sachets over 16 weeks significantly improves urinary iodine concentration.

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